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How to determine the intestinal bacteria (flora) transplant solution? More important than test results.

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2018.05.02

次世代型腸内フローラ移植

Thankfully, we are receiving an increasing number of inquiries about the transplantation of intestinal bacteria (plexus) to our research group.
In particular, we have received inquiries from an increasing number of people with intestinal diseases, atopic allergies, depression, and even those with intractable diseases.

Some of the people who contact us are American and Chinese.

We also receive inquiries from those who are going for transplants asking, “Don’t I have to wait for the results of the flora balance test?” We also receive inquiries such as “Do I have to wait for the results of the FloraBalance test?

Now that we have more cumulative transplant results and know the trends, the results of prior intestinal flora balance testing rarely affect the adjustment of the transplantation solution.

However, if you were born and raised abroad or have a disease that we do not have experience with, you may have to wait up to one month for the test results.

Many people think that the original flora balance is based on the test results and that the fungal solution is adjusted accordingly, but even with the same flora balance, the adjustment policy of the transplanted fungal solution may be changed.

You don’t have to look at the flora balance to know what bacteria you need.

To begin with, I will discuss the concept of “fecal microbiota transplantation” as practiced in Japan and abroad.

To begin with, the concept of the “fecal microbe transplantation” method

糞便微生物移植

Donors for fecal microbiota transplants that are undergoing clinical trials in Japan are basically considered healthy persons within the second degree of kinship. (Some university hospitals have lifted the restriction.)

In other countries, more research has been done and donor banks exist in some countries, and some people sell stools to make a living.

At present, the common domestic and international approach is based on the idea that a healthy balance should be added to a diseased flora balance.

It is becoming clearer through research that the intestinal flora balance is in a certain state of disruption when a person is ill, and it is recognized that any kind of disruption can be cured if the balance is restored to normal.

For example, suppose the state of the diseased intestinal flora is “boiling water” or “half-frozen water”.
In contrast, when room temperature water is added, the image is that of water that is close to room temperature.

The Gut Flora Transplant Clinical Study Group’s method is just a little different.

The most important factor in achieving the original flora balance is ____.

問診

Bringing boiling or half-frozen water to room temperature by adding room temperature water is somewhat inefficient.

Wouldn’t it be better to put ice in boiling water or boiling water in half-frozen water?

This is how we adjust the bacterial solution.

To do this, we need donors of various patterns.

Volunteer donors can receive routine testing that would cost hundreds of thousands of dollars if they were to receive it on their own.
(As of September 2018, we are not accepting new donors.)

What is the most important thing when adjusting the transplantation fungal solution?

It is “a medical interview by a physician.

The Gut Flora Transplant Clinical Study Group questionnaire is very long.

We will obtain as much information as time permits and build up a picture of the person as a whole, including not only his/her daily habits, such as eating habits, sleep, and preferences, but also
his/her perceived personality, how others perceive him/her, the way he/she talks, the way he/she thinks,
any illnesses he/she has had, any discomfort he/she feels in everyday life,
family structure, pets, living environment, occupation,
any major stress he/she has had in the past, and so on. We will obtain as much information surrounding the person as time allows, and build up an overall picture of the person.

When you receive your transplant, please talk a lot with your doctor, both before and during the transplant period.

And during the transplant, try to enjoy the series of small changes that occur in your own body.

Don’t focus too much on “whether or not the disease is cured.”
There should be a series of changes in your body, such as “waking up in the morning,” “change in food preferences,” “tiredness,” and “poop condition.”

It is also important that you continue to live a life that welcomes the transplanted intestinal bacteria.

When test results are needed

検査結果

In such a way, we determine the balance of the transplantation bacterial solution in the initial stage of transplantation and adjust the concentration according to the patient’s condition.
(Reference: Bacteria (plexus) in the gut bacteria (plexus) transplantation bacteria solution photo release! How many bacteria are there?)

Then, after the completion of one course, and in some cases during the duration of one course, it may be necessary to fine-tune the balance of the transplanted bacteria solution.

If the process of getting people well is divided into several stages, fine-tune the process by saying, “We have achieved our initial objective in the first few sessions, so let’s aim for the next target.

Thus, the results become important at “the time to try to consider once the transplant is complete.
Sometimes, “With this flora balance, with this bacterial fluid, this reaction means ……” can tell us whether the cause of what is appearing as a symptom is due to a hormonal imbalance, for example, or to an early tumor.

In addition, results of hospital blood tests and other tests will be collated, if necessary.

By the way, our bacteria artisans have three special skills.
If we hide the patient’s information and show only the flora balance, we can tell his/her symptoms and personality.

On the other hand, if you just give the patient information and ask them to make a flora balance graph, it is usually right when the results come out.
This is written in a simple way, but don’t you think it’s amazing?

We’ve talked about this before.

Basically, the idea is to have healthy intestinal flora. Thanks to this special technique, we are able to adjust the bacteria solution to suit the individual without having to look at the results.

What are the results of the intestinal flora balance? Most of you are probably wondering, but we cannot show you the results of the test.

Because the intestinal flora balance results do not reflect everything, similar results can be adjusted for different personalities and living conditions.

This is because the description of each bacterium is not yet definitive, it is difficult to decipher, and the method of producing test results is patented by other companies.
For research purposes, we ask for your cooperation in stool testing before and after transplantation.

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