About Treatment

Intestinal bacteria flora transplant process

The following is an explanation of the implantation process with the NanoGAS®-FMT procedure.
The flow may be back and forth depending on the patient’s wishes and condition.
For more details, please consult an affiliated medical institution belonging to the Intestinal Flora Transplantation Clinical Research Foundation.

Reservations

Please contact our affiliated medical institutions.
If you do not have a medical institution in mind, please contact us using this form.

Conventional FMT method

Currently in Japan, a study is being conducted as a clinical trial at several universities for a limited number of diseases.
Only patients who meet the requirements during the application period can participate in the study.

Medical examination

We believe it is important for patients and their families to be able to undergo transplants with their full consent.
We believe that the more patients and their families understand about transplantation, and the more doctors and nurses hear directly from patients and their families, the better the treatment will be.

Intestinal microbiome test

The intestinal microbiome test is a method to estimate the composition of bacteria species living mainly in the intestinal tract by reading the nucleotide sequence of the part containing the genetic information (16S rRNA gene) of the microorganisms in the feces using the latest genetic analysis device called a next-generation sequencer and comparing it with a bacterial group classification database. This test is a method of estimating the composition of bacteria species inhabiting the intestinal tract and is not intended to medically diagnose the subject’s health condition. By taking the test before and after the transplant, we can make a transplantation plan tailored to each individual patient’s condition.
Please note that you will be asked to fill out an online medical questionnaire in advance.

Medication

No prior antibiotics are required to perform the transplant. This is a less burdensome procedure for the patient.
(Taking antibiotics for a period of time may compromise the diversity of your own intestinal flora.)

Conventional FMT method

Antibiotics are taken for a period of time.

Donor selection – Japanbiome

Stools are used from donors to Japanbiome, the only stool bank in Japan for transplantation of intestinal bacteria (flora). Japanbiome donors undergo thorough examinations on a regular basis and the donated stools are frozen and stored. Only after passing the next inspection is the frozen stool provided since the previous inspection used.

Conventional FMT method

Patients typically use fresh stool donated by relatives within a second degree of kinship. If no suitable person is available, the patient can be referred to a donor.

Donor selection – Individualization

Based on our experience in transplanting intestinal flora in patients with various diseases, we adjust the bacterial solution for each patient individually based on the results of the patient’s intestinal microbiome test, the contents of the online medical questionnaire, and the physician’s interview.

Purification method ①Solvent

In the transplantation of intestinal bacteria (flora), the micro-foam characteristics of NanoGAS® water enable the effective establishment of other people’s intestinal bacteria that might otherwise be blocked by autoimmune functions such as IgA (immunoglobulin A) and be prevented from successfully taking up residence.

Conventional FMT method

The bacteria should be transplanted immediately after purification of the solution because the growth of the bacteria begins immediately after dissolving in saline solution and changes the balance.

Purification method ② Concentration

To reduce the phenomenon of temporary confusion when the patient’s immune system recognizes the difference between the intestinal bacteria of others and the patient’s own intestinal bacteria, multiple transplants are performed in a short period of time in a systematic manner. Another feature of this method is to gradually increase the concentration of bacteria to ensure effective retention.

Dosing

Since the procedure is performed by catheter injection without using an endoscope,
there is no need for prior bowel cleansing or dietary restrictions, and the procedure is less burdensome.
If you have gas after leaving the treatment room after transplantation, please be sure to dispose of the gas on the toilet seat.
The liquid that held the bacteria will come out with the gas, but please be assured that the bacteria have settled in the intestinal tract.

Conventional FMT method

Because it is administered via colonoscopy, this is a burdensome method that involves prior bowel cleansing with the administration of laxatives and dietary restrictions.

Frequency

Several transplants are then performed with the NanoGAS®-FMT procedure gradually increasing the concentration of bacteria to prevent your immune system from recognizing the new flora balance as “foreign”.
We may initially suggest a course of three to six sessions, but this varies greatly depending on the type of disease, the number of years affected and the progress of the disease.
In addition, there are individual differences depending on the patient’s constitution, lifestyle and other factors. We will give you a general plan at the first consultation and then monitor your condition while transplanting.

Conventional FMT method

After transplantation, regular visits to the hospital for endoscopic examinations are necessary.

Reexamination and follow-up

Please consult with your physician regarding retesting to confirm the intestinal flora balance during and after the transplant period.

Watch the video Transplantation process of intestinal bacteria (plexus)

This video is filmed with consent to provide a simplified explanation of the procedure for patients considering transplantation. For detailed safety management rules on the part of the medical institution, the transplant procedure is performed in accordance with the regulations of the Ethics Committee.