Handling of FMT (fecal microbiota transplantation) in various countries and summary of regulations and guidelines

When performing medical treatment, there are quite strict laws in Japan and abroad.What are the laws and regulations around FMT? FMT was already in place before regulations began, and as the use of FMT became more widespread, countries began to regulate it later. The method of implanting microbiome suspensions (bacterial fluid) derived from other people’s stool into patients is very unique and shows the individuality of each country in its handling. The following list is a synthesis of the paper […]

History of FMT (Fecal Microbiota Transplantation)

Table of Contents The numbers in parentheses in the text refer to the reference numbers at the bottom of the article. China in the 1.4th century The earliest surviving historical description of FMT (fecal microbiota transplantation) is found in a book on emergency medicine called Zhou Hou Bei Ji Fang, written by Ge Hong during the Jin Dynasty in 4th century China. この本では、重症の下痢や食中毒、熱病、腸チフスなどの症状に対して、健康な人の便を「消化管経由で」与えるという記述がある。黄色スープなどとして表現を和らげているものの、口から飲む場合には抵抗があったに違いないが、天秤にかけているのは命なのだ。背に腹は変えられない思いで飲んだのだろう。 We feel disgusted by excrement not only because it is human culture. The sensation is also a […]

Why does eating yogurt reduce sweaty smell and make my skin chewy? [Reader Question.

発酵食品を食べると、体調がいい。そういうお声はよく聞きます。発酵が終わっているので、消化器への負担も少なくて済むのだとか。 Today we received a reader’s question regarding yogurt. 質の良いヨーグルトを毎日食べるようになり、汗臭さを感じなくなりました。（汗の中の雑菌どこいった？）ヨーグルトを食べているときは肌がモチモチします。何故でしょう？ Mr. C. Thank you for your question.I will answer loosely and not too rigidly today. Table of Contents Yogurt and sweat odor I see that yogurt has reduced the smell of sweat. I am very envious. I often say to my sister, “It smells like a gymnast’s club room. I think it might be arousal. Kim Taku had armpit cancer, too, and it seems it can be easily cured with […]

A summary of the current status of FMT in Japan and abroad. (Fecal microbiota transplantation, intestinal flora transplantation)

This article summarizes articles introducing various aspects of FMT (Fecal Microbiota Transplantation, fecal microbiota transplantation), which has been attracting attention as a new treatment method in recent years. The presentation will include a comprehensive overview of national and international regulations, adverse events, donors, and the field of stool banking. We do not mention FMT for each disease, so if you have a disease you would like to know about, please request it. Table of Contents The numbers in parentheses in […]

Babies and the Microbiome “First 1000 Days” (the weight of the first 1000 days)

The expression “First 1000 Days” has great significance for the relationship between the human microbiome and the microbiome. One thousand days is about three years after birth, and the microbiome ecosystem formed during this period is the basis for the face of the partners with whom they will share the rest of their long lives. Where did these numbers come from? *This article is part of the series “By What Age Are Intestinal Bacteria Determined?　The Bacteria That Walk with You […]

At what age are intestinal bacteria determined? The bacteria that walk with you as you grow from baby to child.

Our bodies multiply several times during the first few months of life.And that sharp curve continues through adolescence, although it loosens somewhat. My spiritual development is equally dynamic, but even at 33 years old, I still feel like I am growing spiritually. The rapid increase in height comes to a halt after middle and high school, leaving only the possibility of lateral growth.Cells in the skin, brain, and organs are also replaced daily, but their functions do not develop any […]

no.4 Introduction of Recent Papers on Microbiome Research (Microorganisms, Frontiers of Intestinal Bacteria)

Is it just me or does it seem like there are so many review papers lately…Well, I am very grateful to you for compiling them. I also get the impression that people in the nutrition field are becoming quite interested in the microbiome.I would like to see modern nutritional science updated, such as calories and how to divide them into “carbohydrates, fats, and proteins”, as they are becoming quite outdated. With genomic analysis technology readily available, the number of publications […]

TOILET SEAT STRETCH” RELIEVES CONSTIPATION ON THE TOILET SEAT AND INCREASES THE FECAL VALUE.

In this issue, we will introduce stretches that can relieve constipation. It is often said that an imbalance in the intestinal flora can cause constipation or diarrhea, and that we should adjust the intestinal flora by eating fiber and exercising moderately. However, the opposite is also true. In other words, ongoing constipation further deteriorates the intestinal flora balance, causing abdominal discomfort and gas. When intestinal flora imbalance leads to constipation, it is often difficult to cure it with diet and […]

Seven articles to improve intestinal flora balance through diet

About 100 trillion intestinal bacteria live in the intestines and perform many very important functions for physical and mental health.They are generally called “good bacteria,” “bad bacteria,” or “opportunistic bacteria,” but they are all necessary. There are as many as 30,000 types of intestinal bacteria that have been found at this point in time.The type and balance of bacteria each person has is different, and this balance is called “intestinal flora balance. A wide variety of intestinal bacteria live in […]

U.S. FDA APPROVES FIRST FECAL MICROFLORA PRODUCT

On November 30, 2022, the U.S. Food and Drug Administration (FDA) approved FerringPharma’s fecal microbiota product, Rebyota, for the treatment of rCDI, the first time the FDA has approved a fecal microbiota product. Rebyota is approved for the prevention of recurrent recurrent Clostridioides  difficile infection (CDI) in patients 18 years of age and older. The drug is intended for patients 18 years of age and older with recurrent CDI who have completed treatment with antibiotic therapy and is administered as […]