— An Adjunctive Treatment to Maximize the Efficacy of Fecal Microbiota Transplantation (FMT)
In recent years, interest in fecal microbiota transplantation (FMT) has been growing as a treatment aimed at improving the intestinal environment. Some medical institutions affiliated with the Clinical Research Society for Fecal Microbiota Transplantation have begun using high-concentration hydrogen NanoGAS® water as an adjunctive measure to help restore the intestinal environment to a normal state more quickly.
Please check the “Affiliated Medical Institutions” page to find medical institutions that perform high-concentration hydrogen NanoGAS®︎ water enemas. The information for each institution will include the notation “High-concentration hydrogen NanoGAS®︎ water enema: Available.”
Affiliated Medical Institutions:https://fmt.sym-biosis.co.jp/en/medical-institutions/partners
Produced using specialized technology, this high-concentration hydrogen NanoGAS® water possesses unique physical properties distinct from conventional saline solution. It helps regulate the intestinal environment and serves as “soil preparation” to aid in the colonization of bacteria transplanted during fecal microbiota transplantation.
What Is “High-Concentration Hydrogen NanoGAS® Water” with the Strongest Reducing Power?
High-concentration hydrogen NanoGAS® water contains a significantly higher concentration of hydrogen-containing bubbles compared to standard hydrogen NanoGAS® water.
Hydrogen NanoGAS® water is a proprietary technology of Shinbiosis Corporation and is used to prepare bacterial suspensions for fecal microbiota transplantation. It involves applying a special processing method to water—a compound that, despite being ubiquitous, is considered one of the most poorly understood.
Hydrogen molecules are trapped within the bubbles of this water; however, since the size of these bubbles spans both the “nano” and “pico” ranges, they are formally referred to as “nanopico bubbles.” The term “nanopico” is recognized as a registered trademark in Japan.
The Mechanism of High-Concentration Hydrogen NanoGAS® Water
The reason for its remarkably high adjunctive therapeutic effect lies in its powerful reducing potential.
- Maintenance of a High Reduction Potential: Nanopico bubbles can stably retain hydrogen molecules—which possess powerful reducing properties—within the bubbles for extended periods.
- Instant Elimination of Oxidative Stress: Thanks to this high reducing power, high-concentration hydrogen NanoGAS® water has the ability to immediately neutralize reactive oxygen species and reactive nitrogen species—which cause inflammation—within the intestinal tract.
- Role as a “Starter”: By suppressing oxidative stress, it acts as a “starter” to calm excessive activity in the intestinal immune system and simultaneously activate normal metabolic processes (such as the production of short-chain fatty acids).
Supporting the Colonization of Gut Bacteria
Using high-concentration hydrogen NanoGAS® water as a pretreatment for fecal microbiota transplantation (FMT) is expected to efficiently support the colonization of the transplanted bacteria.
“Preparing the Soil” for a Successful FMT
In FMT, high-concentration hydrogen NanoGAS® water plays the following roles.
First, administering high-concentration hydrogen NanoGAS®︎ water via enema neutralizes inflammation (oxidative stress) within the intestinal tract through its powerful reducing power. This immediately establishes a healthy intestinal environment conducive to the colonization of the transplanted bacteria.
About High-Concentration Hydrogen NanoGAS®︎ Water Enemas
Administration Method:
When administering a high-concentration hydrogen NanoGAS®︎ water enema, the dosage and timing are determined based on the physician’s judgment.
Frequency:
- As a general rule, the initial treatment consists of a single administration. Based on the patient’s response, the physician will then determine whether to continue treatment and, if so, the frequency.
- In cases of severe oxidative stress, or to maintain an improved condition, repeated administration (via enema or oral intake) may be necessary.
Frequently Asked Questions
Q1: Is high-concentration hydrogen NanoGAS® water a pharmaceutical product?
No, high-concentration hydrogen NanoGAS® water has not been approved as a pharmaceutical product or quasi-drug; therefore, its expected effects and efficacy have not been approved. For this reason, its use must be conducted as a self-funded medical treatment (not covered by Japanese health insurance) at the discretion of a physician.
Q2: Why is high-concentration hydrogen NanoGAS® water administered via enema before a fecal microbiota transplant (FMT)?
High-concentration hydrogen NanoGAS® water plays a crucial role in “preparing the soil” to increase the clinical response rate (success rate) of FMT.
Q3: Is it effective for constipation and diarrhea?
Both conditions are believed to involve oxidative stress in the intestines. Evidence suggests that neutralizing oxidative reactions with high-concentration hydrogen NanoGAS®︎ water may alleviate both constipation and diarrhea. In particular, for patients prone to constipation, high-concentration hydrogen NanoGAS®︎ water may stimulate intestinal peristalsis. However, please be aware that the expected effects and benefits have not been fully verified.
Q4: What are the risks and precautions associated with using high-concentration hydrogen NanoGAS® water?
Very rare risks that have been reported include abdominal distension (bloating), changes in bowel habits, mild fatigue, and vomiting. If you experience any changes in your physical condition, please consult a doctor immediately.
Conclusion
Due to its powerful reducing properties, high-concentration hydrogen NanoGAS® water is expected to serve as an effective adjunctive treatment for improving the intestinal environment, particularly for enhancing the success rate of fecal microbiota transplantation.
Patients interested in this treatment are encouraged to consult with a medical institution affiliated with the Clinical Research Society for Fecal Microbiota Transplantation.
Costs vary by medical institution.
Please check the affiliated medical institutions page to find facilities that perform high-concentration hydrogen NanoGAS® water enemas. Each institution’s profile will indicate “High-concentration hydrogen NanoGAS® water enema: Available,” so please look for this notation.
Affiliated Medical Institutions: https://fmt.sym-biosis.co.jp/en/medical-institutions/partners
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