Allergic diseases, including atopic dermatitis, food allergies, hay fever, and bronchial asthma, are increasingly prevalent in modern society. These conditions occur when the immune system, which is designed to protect the body, overreacts to external stimuli.
In addition to genetic predisposition, it is believed that factors such as dietary changes, environmental stressors, and disruptions in the intestinal environment contribute to the onset and exacerbation of these conditions.
In recent years, the relationship between allergies and the gut has drawn significant attention. The gut is the first organ to interact with many external stimuli, such as food and bacteria, and approximately 70% of the body’s immune cells reside within it. Consequently, we now understand that an imbalance in the intestinal environment directly impacts immune function, potentially triggering severe allergic reactions.
NanoGAS®-FMT is a procedure aimed at restoring immune balance by regulating the intestinal environment, thereby supporting the relief of symptoms such as itching and inflammation. While it does not directly suppress allergic reactions in the same manner as medication, our goal is to improve the body’s underlying constitution, making it less hypersensitive to allergens.
The Intestinal Environment and Allergic Constitution: Insights from Recent Research
Numerous studies have shown that in individuals with an allergic constitution, beneficial bacteria such as bifidobacteria and butyrate-producing bacteria tend to decrease, while inflammatory bacteria increase. This bacterial imbalance (dysbiosis) weakens the gut’s barrier function, leaving immune cells susceptible to overreaction.
In other words, allergies represent a “dysregulated immune system” and are often deeply connected to an imbalance in the intestinal environment. In NanoGAS®-FMT, we use a bacterial solution made from carefully selected healthy intestinal flora to optimize the gut microbiota and aim to calm immune overactivity.
Clinical reports from Japan and overseas indicate cases where improvements in the intestinal environment led to positive changes, such as:
- Reduction in skin dryness and redness
- Improvement in post-meal discomfort and general malaise
- Alleviation of symptoms during hay fever season
A key feature of NanoGAS®-FMT is that it does not merely “suppress” allergic symptoms but guides the body toward long-term constitutional improvement.
Fecal Microbiota Transplantation (FMT) using NanoGAS® water and Allergic Diseases
Many individuals with allergic diseases possess sensitive skin and mucous membranes that react easily to stimuli. Therefore, when performing fecal microbiota transplantation (FMT), it is crucial to minimize the burden on the intestines.
In NanoGAS®-FMT, we utilize “NanoGAS® water (nanobubble water)” in the preparation of the bacterial solution. This water, which contains nano-level fine bubbles, is designed to enhance the viability of the transplanted bacteria.
Patients with allergies who have received NanoGAS®-FMT have shared feedback such as, “My gut condition stabilized and skin redness decreased,” “I experience less fatigue after meals,” and “I am now able to fall asleep more easily.”
Allergic diseases occur due to a complex interplay of factors, including constitution, seasonality, and stress. NanoGAS®-FMT focuses on the “disruption of the intestinal environment”—a key factor—and is a procedure designed to cultivate a body that is less reactive to allergens from within.
The Flow of Fecal Microbiota Transplantation for Allergic Diseases
NanoGAS®-FMT is safely implemented following a consultation and examination by a physician. The basic flow is as follows:
1. Initial Consultation and Medical Examination
We assess current symptoms (skin, respiratory, food allergies, etc.) and medical history. Following this, a general blood test and an Intestinal Flora Balance Test are performed to determine eligibility for the procedure.
2. Treatment Plan and Lifestyle Support
The number and duration of sessions are determined based on the level of inflammation and the individual’s constitution. Simultaneously, we provide lifestyle support to regulate the gut, including guidance on diet, sleep, and stress management.
3. Implementation of NanoGAS®-FMT
At a medical institution, the dedicated bacterial solution is transplanted into the intestine. The procedure is conducted on an outpatient basis, and hospitalization is not required. After the procedure, the patient records their diet, defecation pattern, and sleep in a digital diary to monitor progress.
4. Follow-up
The physician evaluates changes in the intestinal environment and symptoms at intervals such as 2 weeks, 3 months, and 6 months post-procedure. While confirming the stabilization of inflammation and itching, the interval between sessions is adjusted as necessary.
FMT is a procedure that gradually regulates the constitution rather than providing immediate results. It is important to monitor progress together with a physician while observing changes in the body with patience.
Medical Institutions Handling Allergic Diseases
NanoGAS®-FMT is performed at affiliated medical institutions belonging to The Association for Clinical Research of Fecal Microbiota Transplantation Japan. For example, the following medical institutions provide comprehensive counseling based on the progression of Atopic Allergies:
Tanaka Clinic, Jinzenkai Medical Corporation (Osaka City)
By integrating insights from integrative medicine, they emphasize improving QOL during the treatment of Atopic Allergies.
All affiliated medical institutions use bacterial solution manufactured in dedicated facilities based on a common protocol. If you wish to receive treatment, please first undergo a consultation with a physician to confirm eligibility based on your symptoms and medical history.
For a full list of supporting clinics nationwide, please refer to the guide for affiliated medical institutions. You can search by region or clinical department.
(Link: https://fmt.sym-biosis.co.jp/transplantation/partner)
For information regarding estimated costs and self-pay treatment, please visit the page on transplant costs.
Frequently Asked Questions Regarding Allergic Diseases
Q: Can NanoGAS®-FMT stop allergic symptoms like medication?
A: NanoGAS®-FMT is not a treatment that directly suppresses allergic reactions in the same way as medicine. Our goal is to improve immune balance by regulating the intestinal environment and guide the body toward a constitution that is less prone to allergic reactions.
Q: How long does it take to feel a change?
A: There are individual differences, but it may take several weeks to several months for the intestinal environment to stabilize. In many cases, symptoms such as itching and skin redness gradually subside.
Q: Can children receive the treatment?
A: NanoGAS®-FMT is available for children aged 2 and older. Since the testing protocols and methods for progress monitoring vary by age, please consult with a supporting medical institution for details.
Allergic Disease Related Columns and Materials
You can view columns regarding the relationship between allergies and intestinal flora, as well as constitutional improvement, here:
- Relationship between the intestinal environment and skin abrasions (Blog link coming soon)
- Relationship between bacteria and breast milk (Blog link coming soon)
- Atopic Allergies and the intestinal environment (Blog link coming soon)
Furthermore, research and clinical data regarding allergic diseases are also introduced in the Follow-up Report (Allergy Edition). (Include link if available; otherwise, delete)
Summary of Allergic Diseases
To improve allergic diseases, it is essential not only to “suppress immunity” but also to restore the intestinal environment. By regulating the intestinal flora, NanoGAS®-FMT supports the creation of a body that is less likely to trigger allergic reactions.
Regarding eligibility and details of the procedure, we recommend first scheduling a consultation at a specialized medical institution. Regulating the gut is the first step toward healthier skin, better breathing, and daily comfort.
