Cancer is a condition in which cells proliferate uncontrollably due to genetic changes, affecting various parts of the body. Treatment methods vary significantly depending on the type and stage of the disease, often involving a combination of surgery, chemotherapy, and radiotherapy.
While these treatments have helped many patients achieve remission or prolong life, many individuals also experience a decline in physical condition and Quality of Life (QOL) during their treatment. In recent years, it has become clear that the microbiome is closely linked to the onset and progression of cancer, as well as post-treatment recovery.
Reports indicate that a decrease in the diversity of gut bacteria can disrupt immune function, potentially reducing treatment efficacy and increasing the likelihood of severe adverse events. Therefore, optimizingthe gut environment as a foundation to support cancer treatment is gaining significant attention.
It is important to note that NanoGAS®-FMT is not a direct treatment for cancer. However, it is a complementary procedure aimed at supporting the body throughout the treatment journey by regulating the microbiome to balance the immune system. For those seeking to maintain a positive outlook during treatment or hoping to alleviate fatigue caused by side effects, we offer this solution to regulate the body from within.
The Relationship Between Cancer and the Gut Environment
Recent studies have shown that the microbiome influences immune cell function and the efficacy of anticancer drugs. For instance, research suggests that for immune checkpoint inhibitors such as anti-PD-1 antibodies, treatment efficacy is higher in individuals with a greater abundance of specific beneficial bacteria in the gut.
Conversely, when the balance of intestinal bacteria is disrupted—often due to the use of anticancer drugs or antimicrobials—the gut barrier function declines, which may lead to immune overreaction or chronic inflammation. In such states, persistent symptoms like treatment-related fatigue, indigestion, and defecation patterns often occur.
We aim to stabilize immune function through NanoGAS®-FMT by addressing these disruptions in the gut environment. By restoring alpha/beta diversity in the gut, we believe it is possible to balance overall inflammation and support QOL both during and after treatment.
The Potential and Safety of Fecal Microbiota Transplantation (NanoGAS®-FMT)
NanoGAS®-FMT does not treat cancer itself. However, we have introduced it with the goal of stabilizing the gut environment to build a physiological foundation that supports cancer treatment. If the gut environment is disrupted, immune function becomes imbalanced, making it difficult to recover from the damage caused by treatment.
In NanoGAS®-FMT, we do more than just deliver beneficial bacteria to the gut; we use proprietaryNanoGAS® water to optimize the intestinal environment and support the colonization of intestinal bacteria. As a result, cases have been reported where this approach helped control inflammation and stabilize immune balance.
The procedure is performed under the supervision of a physician. The administration of the bacterial solution is conducted using a painless method, and safety has been confirmed through favorable results in previous cases.
The Process of Fecal Microbiota Transplantation Performed Alongside Cancer Treatment
NanoGAS®-FMT is carried out while respecting the attending physician’s treatment plan to ensure it does not interfere with cancer treatment. The general flow is as follows:
- Initial Consultation
The physician carefully evaluates the patient’s current treatment status and concerns to determine the suitability of the procedure. If you are undergoing cancer treatment, coordination with your attending physician may be necessary. - Pre-testing and Preparation
Following the consultation, a general blood test and an intestinal flora balance test are performed. Depending on the state of the gut environment, nutritional guidance and dietary restrictions may be provided before the procedure. - Procedure (Transplantation)
The dedicated bacterial solution is delivered into the intestine to promote the colonization of beneficial bacteria. By preparing the bacterial solution using NanoGAS® water, pre-treatment before transplantation is unnecessary, which minimizes the physical burden on the body. - Progress Observation
After the procedure, changes in defecation pattern, appetite, and fatigue are recorded, and progress is observed over several weeks to months. Follow-up reports and tests are conducted as needed to confirm the stability of the gut environment.
The purpose of NanoGAS®-FMT, as a complementary approach to cancer treatment, is to provide patients with the resilience to sustain their treatment. It is also an option for those who have experienced treatment interruption due to severe adverse events or those who wish to optimize their physical well-being during the recovery phase.
Medical Institutions Providing Support for Cancer Patients
NanoGAS®-FMT is performed at affiliated medical institutions belonging to The Association for Clinical Research of Fecal Microbiota Transplantation Japan. For example, the following medical institution provides careful consultations based on the progression of cancer:
Ishinkai Yorozu Clinic (Tottori City)
With extensive experience in cancer treatment and integrative medicine, they introduced NanoGAS®-FMT early on as part of improving physical health.
All medical institutions use bacterial solutions manufactured in dedicated facilities based on a common protocol. If you wish to receive treatment, please first undergo a consultation with a physician to confirm suitability based on your symptoms and medical history.
For a list of clinics nationwide, please refer to our directory of affiliated medical institutions. You can search by region or clinical department. (Link: https://fmt.sym-biosis.co.jp/transplantation/partner)
For cost estimates and information on private-pay medical services, please visit the page regarding the transplant fee for fecal microbiota transplantation.
Frequently Asked Questions Regarding Cancer
Q: Can I receive NanoGAS®-FMT while undergoing cancer treatment?
A: Yes, it is possible as long as it does not interfere with your attending physician’s treatment plan. NanoGAS®-FMT is not a medicine but a complementary procedure to regulate the gut environment. It is often utilized to support issues such as fatigue, poor defecation patterns, and loss of appetite during and after treatment.
Q: Is it okay to stop the transplantation sessions mid-course?
A: We recommend consulting with your attending medical institution. NanoGAS®-FMT is positioned as a complementary approach to support current treatment. Under the guidance of a physician, the interval and number of procedures will be adjusted while monitoring changes in your physical condition.
Q: Are there any side effects?
A: In cases performed to date, no clear severe adverse events caused by NanoGAS®-FMT have been reported. In rare cases, temporary diarrhea or bloating may occur, but these usually subside within a few days. If you have any concerns, please consult a physician before the procedure.
Cancer-Related Columns and External Resources
The relationship between cancer and the gut environment is a field of active research both in Japan and overseas. The following columns provide more detailed explanations on immunity, the microbiome, the brain-gut axis, and the mechanism of NanoGAS®-FMT.
- What are immune checkpoint inhibitors essential for cancer treatment?
- The potential for cancer prevention through gut health: Latest research
- The relationship between cancer immunity and intestinal flora
We will continue to publish new insights as clinical data accumulates. If you are considering NanoGAS®-FMT during cancer treatment, please first review our affiliated medical institutions.
Summary
Cancer treatment is a long journey that places a heavy burden on both the mind and body. NanoGAS®-FMT is drawing attention as an option that supports the body’s natural recovery without hindering conventional treatments.
Regulating the gut environment is deeply connected to our innate healing power, including the regulationof immunity and inflammation, appetite, and sleep. For those who are working hard on their treatment but feel, “I want to be even slightly more comfortable” or “I want to restore balance to my body,” NanoGAS®-FMT offers a promising path toward enhancing your recovery.
