{"id":6007,"date":"2025-11-04T09:25:00","date_gmt":"2025-11-04T00:25:00","guid":{"rendered":"https:\/\/fmt.sym-biosis.co.jp\/?post_type=blog&#038;p=6007"},"modified":"2026-07-21T19:09:25","modified_gmt":"2026-07-21T10:09:25","slug":"initiation-of-pre-transplant-preparation-using-high-concentration-hydrogen-nanogas-water","status":"publish","type":"blog","link":"https:\/\/fmt.sym-biosis.co.jp\/en\/blog\/fmt\/initiation-of-pre-transplant-preparation-using-high-concentration-hydrogen-nanogas-water","title":{"rendered":"Initiation of Pre-Transplant Preparation Using High-Concentration Hydrogen NanoGAS \u00ae Water"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u2014 An Adjunctive Treatment to Maximize the Efficacy of Fecal Microbiota Transplantation (FMT)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In recent years, interest in fecal microbiota transplantation (FMT) has been growing as a treatment aimed at improving the intestinal environment. Some medical institutions affiliated with the Clinical Research Society for Fecal Microbiota Transplantation have begun using <strong>high-concentration hydrogen NanoGAS\u00ae water<\/strong> as an adjunctive measure to help restore the intestinal environment to a normal state more quickly.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Please check the \u201cAffiliated Medical Institutions\u201d page to find medical institutions that perform high-concentration hydrogen NanoGAS\u00ae\ufe0e water enemas. The information for each institution will include the notation <strong>\u201cHigh-concentration hydrogen NanoGAS\u00ae\ufe0e water enema: Available.\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Affiliated Medical Institutions:<a href=\"https:\/\/fmt.sym-biosis.co.jp\/en\/medical-institutions\/partners\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/fmt.sym-biosis.co.jp\/en\/medical-institutions\/partners<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Produced using specialized technology, this high-concentration hydrogen NanoGAS\u00ae water possesses unique physical properties distinct from conventional saline solution. It helps regulate the intestinal environment and serves as \u201csoil preparation\u201d to aid in the colonization of bacteria transplanted during fecal microbiota transplantation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Is \u201cHigh-Concentration Hydrogen NanoGAS\u00ae Water\u201d with the Strongest Reducing Power?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">High-concentration hydrogen NanoGAS\u00ae water contains a significantly higher concentration of hydrogen-containing bubbles compared to standard hydrogen NanoGAS\u00ae water.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hydrogen NanoGAS\u00ae water is a proprietary technology of Shinbiosis Corporation and is used to prepare bacterial suspensions for fecal microbiota transplantation. It involves applying a special processing method to water\u2014a compound that, despite being ubiquitous, is considered one of the most poorly understood.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hydrogen molecules are trapped within the bubbles of this water; however, since the size of these bubbles spans both the \u201cnano\u201d and \u201cpico\u201d ranges, they are formally referred to as \u201cnanopico bubbles.\u201d The term \u201cnanopico\u201d is recognized as a registered trademark in Japan.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The Mechanism of High-Concentration Hydrogen NanoGAS\u00ae Water<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The reason for its remarkably high adjunctive therapeutic effect lies in its powerful reducing potential.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Maintenance of a High Reduction Potential: Nanopico bubbles can stably retain hydrogen molecules\u2014which possess powerful reducing properties\u2014within the bubbles for extended periods.<\/li>\n\n\n\n<li>Instant Elimination of Oxidative Stress: Thanks to this high reducing power, high-concentration hydrogen NanoGAS\u00ae water has the ability to immediately neutralize reactive oxygen species and reactive nitrogen species\u2014which cause inflammation\u2014within the intestinal tract.<\/li>\n\n\n\n<li>Role as a \u201cStarter\u201d: By suppressing oxidative stress, it acts as a \u201cstarter\u201d to calm excessive activity in the intestinal immune system and simultaneously activate normal metabolic processes (such as the production of short-chain fatty acids).<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><br>Supporting the Colonization of Gut Bacteria<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Using high-concentration hydrogen NanoGAS\u00ae water as a pretreatment for fecal microbiota transplantation (FMT) is expected to efficiently support the colonization of the transplanted bacteria.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u201cPreparing the Soil\u201d for a Successful FMT<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In FMT, high-concentration hydrogen NanoGAS\u00ae water plays the following roles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">First, administering high-concentration hydrogen NanoGAS\u00ae\ufe0e water via enema neutralizes inflammation (oxidative stress) within the intestinal tract through its powerful reducing power. <strong>This immediately establishes a healthy intestinal environment <\/strong>conducive to the colonization of the transplanted bacteria.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">About High-Concentration Hydrogen NanoGAS\u00ae\ufe0e Water Enemas<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Administration Method:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">When administering a high-concentration hydrogen NanoGAS\u00ae\ufe0e water enema, the dosage and timing are determined based on the physician\u2019s judgment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Frequency:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>As a general rule, the initial treatment consists of a single administration. Based on the patient\u2019s response, the physician will then determine whether to continue treatment and, if so, the frequency.<\/li>\n\n\n\n<li> In cases of severe oxidative stress, or to maintain an improved condition, repeated administration (via enema or oral intake) may be necessary.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"508\" height=\"336\" src=\"https:\/\/fmt.sym-biosis.co.jp\/wp-content\/uploads\/2025\/11\/\u8178\u5185\u74b0\u5883\u30d6\u30ed\u30b0-\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u30d0\u30e9\u30f3\u30b9-4.png\" alt=\"\" class=\"wp-image-6004\" style=\"aspect-ratio:1.5119285681067758;width:620px;height:auto\" srcset=\"https:\/\/fmt.sym-biosis.co.jp\/wp-content\/uploads\/2025\/11\/\u8178\u5185\u74b0\u5883\u30d6\u30ed\u30b0-\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u30d0\u30e9\u30f3\u30b9-4.png 508w, https:\/\/fmt.sym-biosis.co.jp\/wp-content\/uploads\/2025\/11\/\u8178\u5185\u74b0\u5883\u30d6\u30ed\u30b0-\u8178\u5185\u30d5\u30ed\u30fc\u30e9\u30d0\u30e9\u30f3\u30b9-4-300x198.png 300w\" sizes=\"auto, (max-width: 508px) 100vw, 508px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Frequently Asked Questions<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q1: Is high-concentration hydrogen NanoGAS\u00ae water a pharmaceutical product?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">No, high-concentration hydrogen NanoGAS\u00ae water has not been approved as a pharmaceutical product or quasi-drug; therefore, its expected effects and efficacy have not been approved. For this reason, its use must be conducted as a self-funded medical treatment (not covered by Japanese health insurance) at the discretion of a physician.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q2: Why is high-concentration hydrogen NanoGAS\u00ae water administered via enema before a fecal microbiota transplant (FMT)?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">High-concentration hydrogen NanoGAS\u00ae water plays a crucial role in \u201cpreparing the soil\u201d to increase the clinical response rate (success rate) of FMT.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q3: Is it effective for constipation and diarrhea?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Both conditions are believed to involve oxidative stress in the intestines. Evidence suggests that neutralizing oxidative reactions with high-concentration hydrogen NanoGAS\u00ae\ufe0e water may alleviate both constipation and diarrhea. In particular, for patients prone to constipation, high-concentration hydrogen NanoGAS\u00ae\ufe0e water may stimulate intestinal peristalsis. However, please be aware that the expected effects and benefits have not been fully verified.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Q4: What are the risks and precautions associated with using high-concentration hydrogen NanoGAS\u00ae water?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Very rare risks that have been reported include abdominal distension (bloating), changes in bowel habits, mild fatigue, and vomiting. If you experience any changes in your physical condition, please consult a doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Due to its powerful reducing properties, <strong>high-concentration hydrogen NanoGAS\u00ae water<\/strong> is expected to serve as an effective adjunctive treatment for improving the intestinal environment, particularly for enhancing the success rate of fecal microbiota transplantation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Patients interested in this treatment are encouraged to consult with a medical institution affiliated with the <a href=\"https:\/\/fmt-japan.org\/en\" target=\"_blank\" rel=\"noopener\" title=\"Clinical Research Society for Fecal Microbiota Transplantation.\">Clinical Research Society for Fecal Microbiota Transplantation.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Costs vary by medical institution.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Please check the affiliated medical institutions page to find facilities that perform high-concentration hydrogen NanoGAS\u00ae water enemas. Each institution\u2019s profile will indicate <strong>\u201cHigh-concentration hydrogen NanoGAS\u00ae water enema: Available,\u201d<\/strong> so please look for this notation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Affiliated Medical Institutions: <a href=\"https:\/\/fmt.sym-biosis.co.jp\/en\/medical-institutions\/partners\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/fmt.sym-biosis.co.jp\/en\/medical-institutions\/partners<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Related Articles<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u25b6\ufe0e Here, we introduce \u201cHydrogen NanoGAS Water\u201d as a dietary supplement.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-nanogas-fmt wp-block-embed-nanogas-fmt\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"SsulFlgrpY\"><a href=\"https:\/\/fmt.sym-biosis.co.jp\/blog\/fmt\/25053001-2\">\u5065\u5eb7\u88dc\u52a9\u6750\u6599\u300c\u6c34\u7d20NanoGAS\u6c34\u300d\u3068\u306f\uff1f<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u201c\u5065\u5eb7\u88dc\u52a9\u6750\u6599\u300c\u6c34\u7d20NanoGAS\u6c34\u300d\u3068\u306f\uff1f\u201d \u2014 NanoGAS\u00ae \u2013 FMT \u30b5\u30fc\u30d3\u30b9\u30b5\u30a4\u30c8\" src=\"https:\/\/fmt.sym-biosis.co.jp\/blog\/fmt\/25053001-2\/embed#?secret=On65likIuC#?secret=SsulFlgrpY\" data-secret=\"SsulFlgrpY\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2014 An Adjunctive Treatment to Maximize the Efficacy of Fecal Microbiota Transplantation (FMT) In recent years, interest in fecal microbiota transplantation (FMT) has been growing as a treatment aimed at improving the intestinal environment. Some medical institutions affiliated with the Clinical Research Society for Fecal Microbiota Transplantation have begun using high-concentration hydrogen NanoGAS\u00ae water as [&hellip;]<\/p>\n","protected":false},"featured_media":6004,"template":"","tags":[],"blog_cat":[246,241],"class_list":["post-6007","blog","type-blog","status-publish","has-post-thumbnail","hentry","blog_cat-fmt"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"\u2014 An Adjunctive Treatment to Maximize the Efficacy of Fecal Microbiota Transplantation (FMT) In recent years, interest in fecal microbiota transplantation (FMT) has been growing as a treatment aimed at improving the intestinal environment. 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