{"id":3707,"date":"2021-09-09T10:31:00","date_gmt":"2021-09-09T01:31:00","guid":{"rendered":"https:\/\/fmtsymbiodev.wpenginepowered.com\/blog\/is-transplantation-of-intestinal-microbiota-safe-and-effective-for-mild-cases-of-novel-coronavirus\/"},"modified":"2021-09-09T10:31:00","modified_gmt":"2021-09-09T01:31:00","slug":"is-transplantation-of-intestinal-microbiota-safe-and-effective-for-mild-cases-of-novel-coronavirus","status":"publish","type":"blog","link":"https:\/\/fmt.sym-biosis.co.jp\/en\/blog\/gut-disease\/is-transplantation-of-intestinal-microbiota-safe-and-effective-for-mild-cases-of-novel-coronavirus","title":{"rendered":"Is transplantation of intestinal microbiota safe and effective for mild cases of novel coronavirus?"},"content":{"rendered":"\n

EARLY RECOVERY FROM NOVEL CORONAVIRUS INFECTION AFTER UNDERGOING FMT<\/h2>\n\n\n\n

This is a report by Jaros\u0142aw Bili\u0144ski and his research team at the Medical University of Warsaw, Poland.<\/p>\n\n\n\n

(Text of case report)
Rapid resolution of COVID-19 after fecal microbiota transplantation | Gut<\/a><\/p>\n\n\n\n

(English article based on this paper)
Could a Stool Transplant Help Recovery in COVID-19 Patients? | Technology Networks<\/a><\/p>\n\n\n\n

It has been reported that the composition of the intestinal flora changes when a person is exposed to a new type of coronavirus… [1]<\/sup><\/a> [2]<\/sup><\/a> The key point is that transplantation of intestinal flora to improve the intestinal flora can be helpful.<\/p>\n\n\n\n

By the way, how is the “SARS-CoV2” mentioned in the report related to the new coronavirus (COVID-19), SARS-CoV2 is the name of the virus and COVID-19 is the name of the disease.<\/p>\n\n\n\n

Because gut flora is closely related to the immune system and has been reported to be interconnected with the lungs as well… [3]<\/sup><\/a> it seems to be speculated that transplantation of intestinal flora may be effective in new coronavirus infections.<\/p>\n\n\n\n

This case report describes the transplantation of intestinal microbiota in two CDI patients with symptoms of novel coronavirus infection.<\/strong><\/p>\n\n\n\n

<\/p>\n\n\n\n

Case 1: 80-year-old male with multiple diseases<\/h3>\n\n\n\n

[Patient Profile]
\u30fb80 year old male
\u30fbHas a history of CDI (Clostridioides difficile infection)
\u30fbHas multiple other medical complications
\u30fbHas been hospitalized for pneumonia and sepsis<\/p>\n\n\n\n

THIS PATIENT WAS TREATED FOR PNEUMONIA WITH ANTIBIOTICS, BUT HAD A RECURRENCE OF CDI AND WAS GIVEN AN INTESTINAL MICROFLORA TRANSPLANT.<\/p>\n\n\n\n

HOWEVER, ON THE DAY OF THE GUT MICROBIOTA TRANSPLANT, I DEVELOPED A FEVER AND MY CRP, AN INDEX OF INFLAMMATION, ALSO ROSE.<\/p>\n\n\n\n

When tested, he tested positive for a new type of coronavirus (SARS-CoV-2).
Therefore, antiviral medications and CONVALESCENT PLASMA (CP, convalescent patient plasma therapy) were started.
Unexpectedly (it says), two days after FMT, her fever went down and her CRP level also went down.<\/p>\n\n\n\n

Recovery patient plasma therapy” is a method being tested as a potentially effective treatment for new coronavirus infections. However, its effectiveness is still limited. (Reference: Recovery phase patient plasma)<\/a><\/p>\n\n\n\n

Case 2: 19-year-old male, ulcerative colitis<\/h3>\n\n\n\n

[Patient Profile]
\u30fb19 year old male
\u30fbAffected with ulcerative colitis and on immunosuppressive drugs
\u30fbHospitalized for CDI relapse<\/p>\n\n\n\n

An antibiotic called vancomycin was administered for the purpose of treating CDI and the symptoms subsided.
Intestinal microflora transplantation via colonoscopy was performed for the purpose of preventing further CDI.<\/p>\n\n\n\n

FIFTEEN HOURS AFTER THE GUT MICROBIOTA TRANSPLANT, HE DEVELOPED A 39-DEGREE FEVER AND HIS CRP LEVELS ROSE.<\/p>\n\n\n\n

Upon testing, he also tested positive for a new type of coronavirus (SARS-CoV-2).
Since then, his fever has gone down and his CRP values have settled down.<\/p>\n\n\n\n

New coronavirus infection status of patients and donors<\/h3>\n\n\n\n

At what point did the patient become infected with the novel coronavirus?<\/p>\n\n\n\n

Case 1 patient
<\/strong> – Pre-admission testing negative
– Stool test just prior to FMT negative
– Stool test 7 days after FMT positive
– Stool test 14 days after FMT positive
– Stool test 30 days after FMT negative<\/p>\n\n\n\n

Case 2 patient
<\/strong> – Pre-admission testing negative
– Stool test just prior to FMT negative
– Stool test 7 days after FMT positive
– Stool test 14 days after FMT unknown
– Stool test 30 days after FMT negative<\/p>\n\n\n\n

THE DONOR HAS BEEN CONFIRMED NEGATIVE BY TWO NOSE-PLUG TYPE CORONA TESTS AT THE TIME OF STOOL DONATION AND A STOOL PCR TEST ON THE DONATED STOOL.<\/p>\n\n\n\n

What can be derived from the two cases<\/h2>\n\n\n\n\n\n

The authors state that
“Transplantation of the gut microbiota is a safe and effective method for patients with recurrent CDI who are infected with novel coronaviruses.”<\/p>\n\n\n\n


He further speculates
that “FMT may have made the clinical symptoms of new coronavirus infection less severe.<\/p>\n\n\n\n

The two patients in this case are the type of patients who are likely to have severe coronas.<\/p>\n\n\n\n


The antiviral drugs didn’t kick in until about 10 days, and none of the other treatments they were receiving had been shown to be effective against new coronavirus infections.”<\/p>\n\n\n\n

IN ADDITION, THE STOOL PCR TEST FOR NOVEL CORONAVIRUS INFECTION USUALLY STAYS POSITIVE FOR ABOUT 27 TO 47 DAYS, BUT THESE PATIENTS TURNED NEGATIVE IN A SHORTER PERIOD OF TIME.<\/p>\n\n\n\n

In fact, an Italian research team had a similar experience… [4]<\/sup><\/a> and the present report is further supportive of that.<\/p>\n\n\n\n

I think this finding is a very, very interesting report and should not be overlooked.
Although pharmaceutical companies and the government have been leading the fight against coronas by saying that a vaccine would be safe for now, transplantation of intestinal microflora may be safer and more effective.<\/p>\n\n\n\n

The research team will conduct clinical trials with a view to adding gut microbiota transplantation as a standard measure to prevent severe new coronavirus infections.<\/p>\n","protected":false},"excerpt":{"rendered":"

EARLY RECOVERY FROM NOVEL CORONAVIRUS INFECTION AFTER UNDERGOING FMT This is a report by Jaros\u0142aw Bili\u0144ski and his research team at the Medical University of Warsaw, Poland. (Text of case report)Rapid resolution of COVID-19 after fecal microbiota transplantation | Gut (English article based on this paper)Could a Stool Transplant Help Recovery in COVID-19 Patients? | […]<\/p>\n","protected":false},"featured_media":3602,"template":"","tags":[],"blog_cat":[248],"class_list":["post-3707","blog","type-blog","status-publish","has-post-thumbnail","hentry","blog_cat-gut-disease"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/fmt.sym-biosis.co.jp\/en\/wp-json\/wp\/v2\/blog\/3707","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fmt.sym-biosis.co.jp\/en\/wp-json\/wp\/v2\/blog"}],"about":[{"href":"https:\/\/fmt.sym-biosis.co.jp\/en\/wp-json\/wp\/v2\/types\/blog"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fmt.sym-biosis.co.jp\/en\/wp-json\/wp\/v2\/media\/3602"}],"wp:attachment":[{"href":"https:\/\/fmt.sym-biosis.co.jp\/en\/wp-json\/wp\/v2\/media?parent=3707"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fmt.sym-biosis.co.jp\/en\/wp-json\/wp\/v2\/tags?post=3707"},{"taxonomy":"blog_cat","embeddable":true,"href":"https:\/\/fmt.sym-biosis.co.jp\/en\/wp-json\/wp\/v2\/blog_cat?post=3707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}