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Gut Microbiology Articles and News

[AFTER ASD] A DISCUSSION OF PROTOCOLS AND TIME DIFFERENCES FOR IMPROVEMENT IN STOOL TRANSPLANTATION.

Gut Microbiology Articles and News

2019.07.24

Autism and Gut Bacteria

Hello.
Recently, I bring a replacement Air Rhythm because I sweat about 2 liters by the time I get to work.

I wonder what is going on with my sweat glands.
Does this mean that beautiful women with tight pores are less likely to sweat? (Pores are open.)

But I don’t use any antiperspirants or hair removal because I know that if I stop sweating, it’s not good for my body.
I don’t use antiperspirants or hair removal. He’s disgusting! …… Well, my health is more important.

Well, my last article was Autism and Gut Flora Transplantation seems to be a good match. [Discussion of Target Diseases and Methods].

In fact, there is a later report on this study, which was published in April of this year, when the patients were followed for two years after their stool transplants.

Long-Term Benefits of Enterobacterial Transplantation Therapy in Autism and Gut Flora

Autism and Gut Bacteria

I would be happy if you would check the previous article for the research itself.

This follow-up study, in fact, was not originally planned.
However, the parents of the children who had received transplants said, “They are doing so much better! Oh, is that what the others are like? It’s slowly getting better.”
The research team was inspired by these comments. (Very well translated).

Parents are amazing.
Really, really great.

I wonder if the research team and the children had a conversation about how it has been two years since their last meeting, saying, “It’s been a long time, you’ve grown up so big,” or “No, you’ve become very handsome. It’s a very relaxing experience.

Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota

THE PREVIOUS RESULTS SHOWED AN 80% IMPROVEMENT IN GSRS, A MEASURE OF GASTROINTESTINAL SYMPTOMS, AND A SIGNIFICANT IMPROVEMENT IN AUTISTIC SYMPTOMS. THE RESULTS SHOWED THAT THE EFFECT WAS SUSTAINED UP TO 8 WEEKS AFTER TRANSPLANTATION.

According to the research team, at the time of the two-year study, gastrointestinal symptoms had generally remained improved, and autism had improved remarkably.

Specifically, for example, the Childhood Autism Rating Scale (CARS), a measure of autism.
At 8 weeks after the transplant, the improvement on this scale was 23%.
Two years later, it had increased to 47%.

Originally, before transplant therapy, 83% of the children had “severe” ASD symptoms.
After two years, it was found that 17% had severe, 39% had mild to moderate, and the remaining 44% of children were below the cutoff, or healthy.

The diversity of intestinal bacteria was also increased, as were the bacteria that are thought to be less common in children with autism.

Of course, 17% of the children remain severely ill.
For these children themselves and their parents, I think they would be like, “Huh, what are you so happy about? I’m not cured.”

To begin with, and this is not limited to medical care, “talking about living things in numbers” itself may be arrogant and nonsensical.

But with no clear cause or fundamental cure for autism, I think these results are wonderful.
The research team humbly writes something like, “Studies that eliminate the placebo effect are desirable,” but personally, I hope that clinicians will cure more and more children while working on how to maximize the placebo effect.

I may be offended if I say this, but I feel that medical treatment has a placebo effect.

The transplantation of intestinal flora by mouth.

In my last article, I received the following question from a reader in the comments section.
“If anaerobic bacteria are ingested orally, is it conceivable that they could reach the intestines “alive” in a good way?”

Indeed, it is said that under normal conditions, most of them are killed by stomach acid. (Most, not all.)
However, the probiotic industry seems to be gaining momentum after it was discovered that even dead bacteria can be useful.

In two previous articles, I discussed the question of whether the bacteria reach the intestines alive during the Canadian “oral capsule stool transplant”? In the two previous articles, I briefly touched on the question of whether the bacteria reach the intestines alive.

https://shinbiosis.com/fmt/capsule/

Here, he said, “The stomach acid will certainly kill you, but I think I put in a lot of it, so I think I did okay!” I think he was fine because he had a lot of food in him! (I am writing this in a very rough way.)

In the autism study presented in this article, the patients were transplanted orally after taking a stomach acid suppressant.
This is also thought to reduce losses in stomach acid.

But again, the pH of stomach acid is low to protect the body from infectious sources that come in through the mouth. (It is said to be 1.0-2.0 on an empty stomach and 3.0-4.0 after a meal.)
And yet, don’t you think it is undeniable that by suppressing stomach acid, you could be putting yourself at risk?
Recently, it has even been pointed out that there is a possibility that too much stomach medication (both the type that stimulates stomach acid secretion and the type that suppresses it) is being given for everything, and that some inflammation may be occurring due to oral bacteria that should not reach the intestines.

Is there an ideal protocol for each disease?

WE MENTIONED IN THE LAST ISSUE THAT THERE ARE MANY DIFFERENT FMT PROTOCOLS, BUT HERE ARE SOME POINTS THAT ARE UNIQUE TO THIS FMT.

  1. 2-week antibiotic premedication (vancomycin)
  2. Use of stomach acid suppressants
  3. Use of bowel cleansers
  4. Multiple transplants (oral and via rectum)

I’m sorry to say that there are many ways to say “intestinal flora transplant,” “fecal transplant,” “FMT,” and so on.
I’m sorry, but even in the world, there is no set way to say it, and it bothers me too.

This, it seems, is not an ideal approach for every disease.
For example, in the case of Clostridioides  difficile infection, gastric acid suppressants are known to worsen symptoms, and the Canadian study avoided them.

The intestinal cleansing agent used was MOVIPREP, which is also used in Japan.
It is unclear what the research team’s intention was in using the intestinal cleaning agent (did they want to reduce the number of bacteria in the patients’ intestines?) The National Cancer Center report below indicates that the intestinal flora is not changed by the intestinal cleaning agents.

Colonoscopy confirms that the intestinal microbiota does not fluctuate

This article seems to be intended to show that there are no disadvantages in taking bowel cleansers prior to colonoscopy.

And as you know, unlike us humans, intestinal bacteria are capable of rapid generation and proliferation.
The feces we produce every day contains nearly one trillion bacteria each time.

Oh, but looking at the donor’s stool volume, it looks like I have a lot of stool and …… don’t do the math.
If you are a big eater like me, your poop volume will increase. (No wonder.)

Thus, it seems that the protocols should be flexible depending on the disease, its progression, and the age of the patient.
At our affiliated medical institutions, only the method of making the bacterial solution and the delivery route are the same, but no other strict protocols are established.

Although the Clinical Study Group says “clinician-led”, what it really means is “patient-led.”
We may be missing something.
If you read an article in a foreign country that says, “This method is good for this disease. If you have any suggestions, such as “This method is good for this disease, and we would like you to try it,” please contact us.

I think the realization rate would be high if it were us.
I can’t guarantee it, though… (Sorry)

Is there a time lag between the implantation and the effect?

This time, two long years after the transplant, the symptoms had improved dramatically.
This was a coincidental finding, but under normal circumstances, such a time lag in treatment efficacy is unusual.

The main reason why they do follow-up for years in clinical trials, etc., is to see if there are any “adverse effects later on”.
If they’re going to do that, I wish they’d do a proper study on “long-term effects of artificial sweeteners on the human body,” you money-grubbing pig! (something happened)

Sorry, pig.

Sorry for going a little off topic.

In fact, there was a case of a patient in the Gut Flora Transplant Clinical Study Group whose symptoms improved dramatically after a time lag of several months.
I said I was not sure about this case, because it is possible that other factors contributed to the improvement, but that is usually the case with intestinal flora transplantation.

If you are interested, please come to the Study Group’s 3rd General Meeting (September 23, 2019 ).
The general public is welcome to attend.

● “A case of atopic dermatitis showing improvement 4 months after intestinal flora transplantation”
Dr. Masahiko Shirotani, Director, Luke’s Ashiya Clinic

The presentation will include the following, and much more.
And best of all, you get to meet me. (I’d like to emulate that confidence.)

Of course, some patients see changes immediately.

Why is there sometimes a time lag from treatment to intestinal flora transplantation?

I believe there are two reasons for this.

The first is that it is not a symptom-based medicine.
Medicines, I think, are well made, but they approach directly to the place where symptoms are occurring.
On the other hand, regulating intestinal flora is more like integrative medicine.

This may be the reason why intestinal flora transplantation is not easily accepted by today’s western medicine. ……

Second, gut bacteria are often the “first key”.
In other words, if we stand on the idea that the body and mind are all connected, we should have to unlock a number of locks and switch circuits before we get to the superficial symptoms.

For example, let’s say you have the symptom, “I can’t talk to my daughter.

Why?
Because I was told I had no omon and that my mouth stinks. (Dad ……!!!!)

Why do we have a stinky mouth?
It’s an irresistible phenomenon of aging, or that parents and children are genetically wired to smell bad, or that dad only brushes his teeth once every two days.

Thus, when you factor it out, you can see various causes. It’s like a bucket shop making money when the wind blows.
Then maybe, if I start brushing my teeth every morning and night, my bad breath will disappear and my daughter will talk to me more than I thought.
It might take a couple of years for the bad breath to disappear, though.

I believe that “tooth brushing” is the “intestinal flora transplant” here.
It may not be the only cause, but by changing that, other causes may be resolved.
Finally, I might be able to get along with my daughter.

By the way, I am very close with my father.

When I wrote it down, it came down to the same one reason, not two.

Psychology seems to have realized this at a rather early stage, but it does not seem to be a major concept yet in the medical community in the physical touch area.
I have written about this before.
Gut Bacteria and Us are One, and Integrative Medicine is a Story

Well, that’s all for today.

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